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KMID : 0363020120420020050
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Journal of Korean Academy of Periodontology
2012 Volume.42 No. 2 p.50 ~ p.58
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Periodontal tissue reaction to customized nano-hydroxyapatite block scaffold in one-wall intrabony defect: a histologic study in dogs
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Lee Jung-Seok
Park Weon-Yeong
Cha Jae-Kook
Jung Ui-Won
Kim Chang-Sung
Lee Yong-Keun
Choi Seong-Ho
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Abstract
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Purpose: This study evaluated histologically the tissue responses to and the effects of a customized nano-hydroxyapatite (n-HA) block bone graft on periodontal regeneration in a one-wall periodontal-defect model.
Methods: A customized block bone for filling in the standardized periodontal defect was fabricated from prefabricated n-HA powders and a polymeric sponge. Bilateral 4×4×5 mm (buccolingual width×mesiodistal width×depth), one-wall, critical-size intrabony periodontal defects were surgically created at the mandibular second and fourth premolars of five Beagle dogs. In each dog, one defect was filled with block-type HA and the other served as a sham-surgery control. The animals were sacrificed following an 8-week healing interval for clinical and histological evaluations.
Results: Although the sites that received an n-HA block showed minimal bone formation, the n-HA block was maintained within the defect with its original hexahedral shape. In addition, only a limited inflammatory reaction was observed at sites that received an n-HA block, which might have been due to the high stability of the customized block bone.
Conclusions: In the limitation of this study, customized n-HA block could provide a space for periodontal tissue engineering, with minimal inflammation.
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KEYWORD
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Bone substitutes , Guided tissue regeneration , Periodontal disease , Tissue engineering , Tissue scaffolds
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